Diagnosis and Management of Drug-induced Stevens-Johnson Syndrome: Report of Two Cases

Erythema multiforme (EM) is a typically mild, self-limiting and recurring mucocutaneous reaction characterized by target or iris lesions of the skin and mucous membranes. It is most often a recurring phenomenon with great variability in the interval between episodes. It is much more common in persons under 40 years of age. In contrast, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are less common and more severe conditions that typically occur in adults. SJS and TEN are severe variants of EM usually caused by a drug exposure. We report two cases of Stevens-Johnsons syndrome following drug intake. There is an increased incidence of SJS and TEN in the HIV-infected population.1 Herewith, we report two cases of Stevens-Johnson syndrome in one patient following drug intake and other in a HIV-infected patient.